There is more and more research with ethnogens and psychoactive substances going on now for treating mental health issues. Besides E, there is some research into using psilocybin (mushrooms)in helping treat anxiety issues with cancer patients and such.
And hate to break it to you, but drooping of your defenses is going to happen in any situation using these substances, controlled or other wise. And from my understanding that is the primary mode of action and pretty much the whole point of taking them. From what Ive read, the good you get out of these drugs comes from the fact that they force you, no matter if you want to or not, to really wrestle with things. They make you really see things in a very truthful manner, no delusions that you can hide behind. And sometimes the truth is very unpleasant, disturbing, and even excruciatingly painful. But sometimes a strong medicine that tastes disgusting is needed for a virulent illness. So be wary of that if anyone might want to try this in the future if it were to become more available.
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“How'd you like to gaze at a beer can throughout eternity? It might not be so bad. There'd be nothing to fear.”